Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 7-hydroxy-6-methoxy-3-[(2-oxo-2H-1-benzopyran-7-yl)oxy]-2H-1-benzopyran-2-one
Purity: ≥98%
Formula Markup: C19H12O7
Formula Weight: 352.29438
CAS Number: 2034-69-7
Notes: Daphnoretin is a coumarin that has been found in W. indica and has diverse biological activities.{48370,48371,48372} It induces aggregation of washed rabbit platelets (EC50 = 17.2 μM), an effect that is reversed by the protein kinase C (PKC) inhibitor staurosporine (Item No. 81590).{48370} Daphnoretin is active against respiratory syncytial virus (RSV) in a plaque reduction assay using HEp-2 cells (IC50 = 5.87 μg/ml).{48371} It halts the cell cycle at the G2/M phase, induces apoptosis, and inhibits proliferation of human osteosarcoma (HOS) cells (IC50 = 3.89 μM).{48372} Daphnoretin also reduces proliferation, invasion, and migration of HCT116 colon cancer cells in a concentration-dependent manner.{48373}
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