Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4,4'-sulfonylbis-benzen-2,3,5,6-d4-amine
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C12H4D8N2O2S
Formula Weight: 256.3
CAS Number: 557794-38-4
Notes: Dapsone-d8 is intended for use as an internal standard for the quantification of dapsone (Item No. 23743) by GC- or LC-MS. Dapsone is an anti-inflammatory, antimalarial, and antibacterial compound.{28213} In vivo, dapsone (34 μg/animal per day) reduces epidermal hyperproliferation and epithelial thickness in the esophagus in a mouse model of proliferative dermatitis.{38501} It reduces lipid peroxidation, myeloperoxidase activity, and cellular apoptosis in the striatum of rats following ischemia and reperfusion injury.{38502} Dapsone reduces growth of M. leprae in the footpad of mice (MIC = 0.01-0.03 μg/ml in sera) and induces clearance of P. knowlesi infections in macaques.{38503,38504} It also reduces the number of P. gallinaceum sporozoites in a mosquito population allowed to feed on dapsone-treated chicks.{38504} Formulations containing dapsone have been used in the treatment of malaria, acne, dermatitis, and leprosy.
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