Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl-2,2’,3,3’,5,5’,6,6’-d8]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Purity: ≥99% deuterated forms (d1d8); ≤1% d0
Formula Markup: C22H18ClD8N7O2S
Formula Weight: 496.1
CAS Number: 1132093-70-9
Notes: Dasatinib-d8 is intended for use as an internal standard for the quantification of dasatinib (Item No. 11498) by GC- or LC-MS. Dasatinib is a potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family.{24166,24167} It is effective at sub-nanomolar concentrations, inhibiting Src, Abl, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively.{24166,24156,24168} At nanomolar concentrations, dasatinib also blocks the activity of several other receptor and non-receptor tyrosine kinases, plus drug-resistant mutants.{24156,24168} Because of these activities, dasatinib has potential therapeutic value in diseases characterized by elevated levels of these kinases, including some forms of cancer and fibrotic disease.{24166,24164,17350,17482}
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