Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 8S-acetyl-10S-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-(methoxy-13C-d3)-5,12-naphthacenedione
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C26[13C]H26D3NO10
Formula Weight: 531.5
Notes: Daunorubicin-13C-d3 is intended for use as an internal standard for the quantification of daunorubicin (Item No. 14159) by GC- or LC-MS. Daunorubicin is an antitumor antibiotic.{22542} At 0.2-1 μM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations.{22542} In mature AML cells, daunorubicin has been shown to trigger a reactive oxygen species-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.{5396,22542}
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