Product Description: DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.
Applications: Cancer-programmed cell death
Formula: C22H20N4
References: [1]Chou TF, et al.Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9./[2]Zhang Y, et al. The AAA ATPase Vps4 Plays Important Roles in Candida albicans Hyphal Formation and is Inhibited by DBeQ. Mycopathologia. 2016 Jun;181(5-6):329-39.
CAS Number: 177355-84-9
Molecular Weight: 340.42
Compound Purity: 99.68
Research Area: Cancer
Solubility: DMSO : 35.71 mg/mL (ultrasonic)
Target: Apoptosis;Autophagy;p97