Product Description: DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively)[1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis[2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C16H18FNO2S
References: [1]Hu H, et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009;390(3):557-563./[2]Wu J, et al. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis [published correction appears in J Cell Biochem. 2013 May;114(5):1216]. J Cell Biochem. 2012;113(4):1152-1158.
CAS Number: 346692-04-4
Molecular Weight: 307.38
Compound Purity: 99.74
Research Area: Metabolic Disease
Solubility: DMSO : ≥ 100 mg/mL
Target: Apoptosis;Free Fatty Acid Receptor
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