Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 8,14-dihydro-14-methyl-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, monohydrochloride
Purity: ≥98%
Formula Markup: C19H15N3O / HCl
Formula Weight: 337.80266
CAS Number: 111664-82-5
Notes: Dehydroevodiamine is an alkaloid that has been isolated from E. rutaecarpa and has anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.{37668,37669,37670,37671} It inhibits LPS-induced secretion of prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 mouse macrophages when used at a concentration of 30 μM.{37668} Dehydroevodiamine (0.1-0.3 μM) reduces the upstroke velocity, action potential amplitude, and contractile force of electrically-stimulated primary human atrial trabeculae.{37669} In vivo, dehydroevodiamine (10 mg/kg) decreases mean arterial blood pressure (MAP) by approximately 30% in rats.{37670} Dehydroevodiamine (1.5 mg/kg) also inhibits amnesia induced by amyloid-β (25-35) (Item No. 24155) and increases latency to step-through in a passive avoidance test in mice.{37671}
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