DEL-22379, CAS 181223-80-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[2,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide

Purity: ≥98% (mixture of rotamers)

Formula Markup: C26H28N4O3

Formula Weight: 444.5

CAS Number: 181223-80-3

Notes: DEL-22379 is an inhibitor of ERK dimerization that disrupts EGF-induced co-immunoprecipitation of ERK tagged with hemagglutinin (HA) or FLAG epitopes with an IC50 value of approximately 0.5 μM without affecting ERK phosphorylation or kinase activity (IC50s = >10 μM).{37660} It inhibits cell growth in a panel of melanoma and colorectal cancer cell lines (IC50s = 150-400 nM). DEL-22379 (15 mg/kg, i.p.) inhibits ERK dimerization in liver extract and tumor tissue and inhibits tumor progression in an A375 mouse xenograft model. It also reduces tumor growth in a BRAF mutant colorectal cancer patient-derived xenograft (PDX) mouse model.

• Artikelnummer: CAY22433-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22433-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK