Product Description: Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26?μM) over DNA polymerase?α?(IC50=440 μM) and polymerase?δ (IC50>550?μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs[1].
Applications: COVID-19-anti-virus
Formula: C22H28N6O3S
Citations: Sci Rep. 2015 Oct 29;5:15806./Future Med Chem. 2018 Dec 17. /Int J Antimicrob Agents. 2019 Dec;54(6):814-819.
References: [1]Dueweke TJ, et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob Agents Chemother. 1993 May;37(5):1127-31./[2]Mayland Chang, et al. Metabolism of the HIV-1 Reverse Transcriptase Inhibitor Delavirdine In Mice. Research Article
CAS Number: 136817-59-9
Molecular Weight: 456.56
Compound Purity: 99.60
Research Area: Infection
Solubility: DMSO : 17.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: HIV;Reverse Transcriptase
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