Product Description: Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA. Demeclocycline shows anti-bacterial activitise to a wide variety of bacterial infections[1][2].
Applications: COVID-19-immunoregulation
Formula: C21H21ClN2O8
Citations: J Photoch Photobio A. 2020 May. /Chemosphere. 2019 Jun;225:378-387. /Mol Syst Biol. 2022 Sep;18(9):e11081./Patent. US20230014181.
References: [1]I Chopra, et al. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29(3):245-77./[2]D Schnappinger, et al. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol. 1996 Jun;165(6):359-69./[3]Marleen L A Kortenoeven, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18./[4]Susobhan Sarkar, et al. Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. Front Immunol. 2020 Feb 21;11:272.
CAS Number: 127-33-3
Molecular Weight: 464.85
Compound Purity: 98.0
Research Area: Cancer; Infection; Inflammation/Immunology
Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : 40 mg/mL (ultrasonic)
Target: Antibiotic;Bacterial
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