Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (5R,5aR,8aR)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity: ≥95%
Formula Markup: C22H22O7
Formula Weight: 398.40588
CAS Number: 19186-35-7
Notes: Deoxypodophyllotoxin (DPT) is a flavolignan that has been found in J. sabina and has diverse biological activities.{64463,64464,64465,46754,64466} It inhibits tubulin polymerization in a cell-free assay when used at a concentration of 50 nM.{64463} DPT in also inhibits COX-2 and 5-lipoxygenase (5-LO) in isolated mouse bone marrow-derived mast cells stimulated with KL, IL-10, and LPS (IC50s = 1.89 and 0.37 µM, respectively).{64464} It reduces viral yield in the supernatant of MRC-5 cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 when used at a concentration of 0.02 µg/ml.{64465} DPT inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) in a concentration-dependent manner.{46754} It induces mortality in P. rapae fifth instar larvae (LC50 = 0.02 g/L).{64466} DPT (70 µg/kg) reduces tumor growth in a CT26 murine colon cancer model.{64463}
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