Product Description: Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
Applications: COVID-19-immunoregulation
Formula: C18H20N4O
References: [1]Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32./[2]Marta Mateus, et al. Understanding the Role of Adenosine Receptors in the Myofibroblast Transformation in Peyronie's Disease. J Sex Med. 2018 Jul;15(7):947-957.
CAS Number: 251945-92-3
Molecular Weight: 308.38
Compound Purity: 99.93
Research Area: Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Adenosine Receptor
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