Description: Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potential chemopreventive and antineoplastic activities, and has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Advanced Cancer, and Pancreatic Cancer, among others.
CAS Number: 95809-78-2
Formula: C22H28O2S2
Molecular Weight: 388,59
References: Zachar Z, et al. J Mol Med (Berl). 2011, 89(11), 1137-1148.