Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4,5-dichlorobenzene-1,3-disulfonamide-1,2,3,4,5,6-13C6
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: [13C]6H6Cl2N2O4S2
Formula Weight: 311.1
CAS Number: 1391054-76-4
Notes: Dichlorphenamide-13C6 is intended for use as an internal standard for the quantification of dichlorphenamide (Item No. 23658) by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).{36212} It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye.{36213} Dichlorphenamide rescues the potassium deficiency and prevents insulin-induced paralysis in a rat model of familial hypokalemic periodic paralysis when administered at a dose of 5.6 mg/kg per day for ten days.{36214} Formulations containing dichlorphenamide have been used in the treatment of glaucoma and primary periodic paralysis.
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