Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-[(2,6-dichlorophenyl)amino]-benzene-2,3,4,5-d4-acetic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C14H7D4Cl2NO2
Formula Weight: 300.2
CAS Number: 153466-65-0
Notes: Diclofenac-d4 is intended for use as an internal standard for the quantification of diclofenac (Item Nos. 70680 / 22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively).{1791,1286} It is also an active metabolite of diclofenac methyl ester (Item No. 22218) and diclofenac amide (Item No. 21969).{45201,52034} Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) induced by A23187 (Item No. 11016) in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively).{61276} Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats.{61277} Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
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