Product Description: Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
Applications: COVID-19-immunoregulation
Formula: C14H10Cl2KNO2
Citations: Biotechnol Bioeng. 2021 Sep 3./ACS Infect Dis. 2024 Jul 29./Arch Microbiol. 2024 Jun 7;206(7):289./Biotechnol Bioeng. 2021 Sep 3./Cell Rep Methods. 2023 Oct 23;3(10):100599./Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. /Toxicol Mech Methods. 2019 Nov;29(9):654-664./bioRxiv. 2024 Apr 7./Biotechnol Bioeng. 2021 Sep 3./Chem-Biol Interact. 2021, 109425./Chemosphere. 2019 Jun;225:378-387. /Eur J Drug Metab Pharmacokinet. 2022 Jun 22./Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov./Int J Mol Sci. 2022, 23(20), 12066./J Hazard Mater. 2015 May 30;289:18-27./J Pharmaceut Biomed. 2021, 114105./J Phys Chem Solids. 2017 October;109:117-123./Pharm Res. 2022 Aug 24.
References: [1]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95./[2]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17./[3]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.
CAS Number: 15307-81-0
Molecular Weight: 334.24
Compound Purity: 99.99
Research Area: Inflammation/Immunology; Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Apoptosis;COX
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