Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2',3'-dideoxy-inosine-2,8-d2
Purity: ≥99% deuterated forms (d1-d2)
Formula Markup: C10H12D2N4O3
Formula Weight: 240.25544
Notes: Didanosine-d2 is intended for use as an internal standard for the quantification of didanosine (Item No. 23715) by GC- or LC-MS. Didanosine is an antiviral nucleoside analog and an inhibitor of reverse transcriptase.{38655} It undergoes cellular amination and phosphorylation to its active triphosphate form, 2',3'-dideoxyadenosine 5'-triphosphate (ddATP; Item No. 17460). Didanosine inhibits human T cell leukemia virus type 1 (HTLV-1) reverse transcriptase activity (IC50 = 30 nM).{60704} It inhibits the replication of HIV-1 clinical isolates containing various mutations in the gene encoding reverse transcriptase, pol, in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-11.1 μM).{38656} Didanosine inhibits proliferation and differentiation of primary human skeletal muscle cells (IC50s = 1 and 0.1 mM, respectively), as well as decreases the activities of mitochondrial complex IV, also known as cytochrome c oxidase, and mitochondrial complex II, also known as succinate dehydrogenase, in the same cells when used at a concentration of 1 mM.{38657} In vivo, didanosine protects mice from HIV infection (EC50 = 13.7 mg/kg).{38658} Formulations containing didanosine have been used in the treatment of HIV-1 infections.
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