Product Description: Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease[1][2].
Applications: Neuroscience-Neurodegeneration
Formula: C27H44N4O5
References: [1]Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402./[2]McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013 Jan;344(1):141-54.
CAS Number: 1401708-83-5
Molecular Weight: 504.66
Compound Purity: 98.92
Research Area: Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: c-Met/HGFR
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