Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 5,7-dihydroxy-2-(3-hydroxy-4-methoxy-d3-phenyl)-4H-1-benzopyran-4-one
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C16H9D3O6
Formula Weight: 303.28106
CAS Number: 1189728-54-8
Notes: Diosmetin-d3 is intended for use as an internal standard for the quantification of diosmetin (Item No. 18649) by GC- or LC-MS. Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.{30253,49507,49508,49509} It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively).{30253} Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH (Item No. 82235) in a concentration-dependent manner.{49507} It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day.{49508} Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.{49509}
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