Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,2',2",2"'-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-ethanol-1,1,2,2-d4
Purity: ≥99% deuterated forms (d1-d16)
Formula Markup: C24H24D16N8O4
Formula Weight: 520.72288
CAS Number: 2712261-50-0
Notes: Dipyridamole-d16 is intended for use as an internal standard for the quantification of dipyridamole (Item No. 18189) by GC- or LC-MS. Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50 = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells.{23680,29326} It also scavenges the free radicals that inactivate cyclooxygenase, leading to the inhibition of platelet activation and thrombin generation.{23680} Dipyridamole has also been shown to inhibit PDE11A with an IC50 value of 370 nM and equilibrative nucleoside transporter 1 (ENT1) with a Ki value of 8.18 nM.{17520,29324} Formulations containing dipyridamole in combination with aspirin have been used to prevent stroke and other cardiovascular events.
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