Product Description: DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C5H12NO5P
Citations: Int J Biol Macromol. 2024 Oct 28:136767./Biomed Pharmacother. January 2022, 112446./Brain Behav Immun. 2023 Jun 5;S0889-1591(23)00141-1./Brain Res. 2019 Dec 15;1725:146487./Cell Death Discov. 2020 Sep 17;6:87./CNS Neurosci Ther. 2022 Nov 15./Environ Sci Technol. 2023 Aug 9./Exp Brain Res. 2023 Oct 16./Front Pharmacol. 2022 Jun 9;13:888308./J Neurochem. 2022 Jul 1./J Neuroinflammation. 2024 Mar 26;21(1):76./Neural Plast. 08 Jul 2021./Neurochem Int. 2023 Jul 24;105587./Research Square Print. August 24th, 2022./Sci Rep. 2024 Aug 20;14(1):19337./Sens Actuators B Chem. 2020, 129190./Theranostics. 2021 Mar 4;11(10):4616-4636./Theranostics. 2023 May 11;13(9):2946-2961.
References: [1]Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185./[2]Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30./[3]Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7./[4]Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23./[5]Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28.
CAS Number: 76326-31-3
Molecular Weight: 197.13
Compound Purity: 98.0
Research Area: Inflammation/Immunology; Neurological Disease
Solubility: H2O : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target: iGluR
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