Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (aR,ßS)-ß-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-benzenepropanoic acid, ß-[[[1,1-di(methyl-d3)ethoxy-2,2,2-d3]carbonyl]amino]-a-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2aR,3,4S,4aS,5,6R,9S,10,11S,12S,12aR,12bS-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C43H44D9NO14
Formula Weight: 816.9
CAS Number: 940867-25-4
Notes: Docetaxel-d9 is intended for use as an internal standard for the quantification of docetaxel (Item No. 11637) by GC- or LC-MS. Docetaxel is a microtubule-stabilizing agent and a semisynthetic derivative of paclitaxel (Item No. 10461).{20977} It promotes microtubule assembly in a cell-free assay when used at a concentration of 20 µM and is cytotoxic to J774.2 cells (EC50 = 0.05 µM).{61884} In vivo, docetaxel inhibits tumor growth in several cancer models, including B16 murine melanoma and P388 murine leukemia models.{20977} Formulations containing docetaxel have been used in the treatment of head and neck, breast, and non-small cell lung cancer, gastric adenocarcinoma, and castration-resistant prostate cancer.
Deutsch
English
