Dorsomorphin, CAS 866405-64-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine

Purity: ≥98%

Formula Markup: C24H25N5O

Formula Weight: 399.5

CAS Number: 866405-64-3

Notes: Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCθ, PKA, and JAK3.{21404} Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6).{23050} Independent of AMPK inhibition, dorsomorphin at 10 μM has additionally been shown to downregulate the Akt/mTOR pathway to induce autophagy in U251 human glioma cells.{23051}

• Artikelnummer: CAY11967-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11967-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK