Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,6-anhydro-5-[[[(3'R,4'S,5'R)-6''-chloro-4'-(2-chloro-3-fluoro-4-pyridinyl)-1'',2''-dihydro-4,4-dimethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indol]-5'-yl]carbonyl]amino]-3,4,5-trideoxy-L-erythro-hexonamide
Purity: ≥98%
Formula Markup: C30H34Cl2FN5O4
Formula Weight: 618.5
CAS Number: 1398568-47-2
Notes: DS-3032 is an inhibitor of the protein-protein interaction between murine double minute 2 (MDM2) and p53.{68913} It induces apoptosis in WaGa and PeTa Merkel cell carcinoma cells when used at a concentration of 100 nM. DS-3032 (1 µM) decreases the viability of p53 wild-type MKL-1 cells but not p53 knockout MLK-1 cells. In vivo, DS-3032 (100 mg/kg per day) reduces tumor volume and increases survival in a patient-derived xenograft (PDX) mouse model of Merkel cell carcinoma.
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