Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-(methyl-d3)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine, monohydrochloride
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C18H16D3NOS / HCl
Formula Weight: 336.89442
CAS Number: 1188266-11-6
Notes: Duloxetine-d3 is intended for use as an internal standard for the quantification of duloxetine (Item No. 14317) by GC- or LC-MS. (S)-Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake (Kis = 4.6 and 15.6 nM, respectively, for rat synaptosomes).{25641} It also inhibits dopamine reuptake (Ki = 369 nM). (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively).{25642} It also decreases immobility time and increases latency to first immobility in the forced swim test in mice when administered at doses of 16 and 32 mg/kg.{41773} Formulations containing (S)-duloxetine have been used in the treatment of major depressive disorder, generalized anxiety disorder, chronic neuropathic and musculoskeletal pain, and fibromyalgia.
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