(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione, CAS 69304-49-0

Product Description: (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

Applications: COVID-19-immunoregulation

Formula: C6H5BrN2O2

References: [1]De Clercq, et al. Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. J. Med. Chem. 29(2), 213-217 (1986).

CAS Number: 69304-49-0

Molecular Weight: 217.02

Research Area: Infection

Target: DNA/RNA Synthesis

• Artikelnummer: MEXHY-W014109-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W014109-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK