(E/Z)-DMU2105, CAS 1031063-36-1

Product Description: (E/Z)-DMU2105 (Compound 7k) is a potent and highly selective CYP1B1 inhibitor. (E/Z)-DMU2105 inhibits human CYP1B1 enzyme bound to yeast-derived microsomes with an IC50 value of 10 nM. (E/Z)-DMU2105 also potently inhibits CYP1B1 expressed within ‘live’ recombinant yeast and human HEK293 kidney cells with an IC50 value of 63.65 nM. (E/Z)-DMU2105 can be used for the research of cancer, glaucoma, ischemia and obesity[1].

Applications: Cancer-programmed cell death

Formula: C18H13NO

References: [1]Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174.

CAS Number: 1031063-36-1

Molecular Weight: 259.30

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Cytochrome P450

• Artikelnummer: MEXHY-101284A-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-101284A-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK