Product Description: Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).
Applications: Neuroscience-Neuromodulation
Formula: C20H25N7O2
References: [1]Kleiman RJ, et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther. 2012 May;341(2):396-409./[2]Hutson, P. H, et al. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and
CAS Number: 1082744-20-4
Molecular Weight: 395.46
Compound Purity: 99.85
Research Area: Neurological Disease
Solubility: DMSO : ≥ 54.6 mg/mL
Target: Phosphodiesterase (PDE)
Deutsch
English
