Elab Fluor® 488 Anti-Mouse CD274/PD-L1 Antibody(10F.9G2)

Target Synonym: B7H1PD-L1PDCD1L1PDCD1LG1PDL1;B7 homolog 1;B7-H;B7-H1;Programmed cell death ligand 1

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Storage: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation Link 1: https://789.bio/ec/HyTG4G

Citation Link 2: C57BL/6 murine splenocytes are stained with APC Anti-Mouse CD3 Antibody and Elab Fluor^® 488 Anti-Mouse CD274/PD-L1 Antibody (Left). Splenocytes are stained with APC Anti-Mouse CD3 Antibody and Elab Fluor^® 488 Rat IgG2b, κ Isotype Control (Right).

Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Artikelnummer: ELSE-AB-F1132L-50
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: E-AB-F1132L-50
• Verpackungseinheit: 50 Tests
• Mengeneinheit: PAK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: Rat IgG2b κ
• Human Gene ID: 60533
• Wirt: Rat
• Konjugat: Conjugated, Elab Fluor488