Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole, monohydrochloride
Purity: ≥98%
Formula Markup: C17H14N2 / HCl
Formula Weight: 282.8
CAS Number: 5081-48-1
Notes: Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II.{30281,30282,30280} It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues.{30282,30280} Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7 µM.{30282}
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