Product Description: EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.
Applications: Cancer-Kinase/protease
Formula: C18H18F2N2O4
References: [1]Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28(1):137-46./[2]Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32(4):838-48./[3]Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14(4):368-78./[4]Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29(9):3737-49.
CAS Number: 1181770-72-8
Molecular Weight: 364.34
Compound Purity: 99.89
Research Area: Metabolic Disease; Cancer
Solubility: DMSO : ≥ 50 mg/mL
Target: SGK
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