Ensartinib, CAS 1365267-27-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide

Purity: ≥98%

Formula Markup: C25H25Cl2FN6O3

Formula Weight: 547.4

CAS Number: 1365267-27-1

Notes: Ensartinib is a potent and selective inhibitor of anaplastic lymphoma kinase (ALK; IC50 50 = 15 nM) but has no effect on cell growth driven by other mutant kinases or that of non-cancerous HepG2 cells. Ensartinib, at a dose of 25 mg/kg, reduces H3122 xenograft growth with no effect on body weight in nude mice. It is also brain-permeable to a concentration of 65 nM.

• Artikelnummer: CAY21341-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21341-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK