Product Description: Entolimod (CBLB-502), a recombinant protein is a toll-like receptor 5 (TLR5) agonist. Entolimod induces a cascade of TLR5-NF-κB signaling resulting in mobilization to the liver of various components of innate and adaptive immunity, followed by suppression of liver metastases and development of long-term antitumor immune memory[1][2].
Applications: COVID-19-immunoregulation
Formula: N/A
References: [1]Brackett CM, et al. Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E874-83. /[2]Hua Yang, et al. The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism. Oncotarget . 2016 Jan 19;7(3):2936-50.
CAS Number: 951628-22-1
Molecular Weight: N/A
Research Area: Cancer; Inflammation/Immunology
Target: Toll-like Receptor (TLR)
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