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Biological Activity: Epacadostat has been reported to restore and increase the proliferation ofvarious immune cells including dendritic cells, NK cells, and T cells in vitro and in vivo.
CAS Number: 1204669-58-8
Description: Epacadostat (INCB024360) is an orally available hydroxyamidine and inhibitor of indoleamine 2,3- dioxygenase (IDO1), with an IC50 of 10 nM. It shows little activity against other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). Epacadostat displays potential immunomodulating and antineoplastic activities.
Format: White powder
Purity: ≥98%
Storage Stability: Store as supplied at or below -20°C for up to 2 years. Stable in DMSO at-80°C for up to 6 months.
Biosafety Level: Not applicable (BSL-1)
References: 1. Koblish, HK., et al., Molec. Cancer Therapeutics. 2010; 9: 489-498.
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