Erlotinib-d6 (hydrochloride), CAS 1189953-78-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-(3-ethynylphenyl)-6,7-bis[2-(methoxy-d3)ethoxy]-4-quinazolinamine, monohydrochloride

Purity: ≥99% deuterated forms (d1-d6)

Formula Markup: C22H17D6N3O4 / HCl

Formula Weight: 435.9

CAS Number: 1189953-78-3

Notes: Erlotinib-d6 is intended for use as an internal standard for the quantification of erlotinib (Item Nos. 10483 / 35517) by GC- or LC-MS. Erlotinib is an EGFR inhibitor (Ki = 2.7 nM).{18353} It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM.{69208} Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM.{18351} Erlotinib (25 mg/kg) reduces EGF-induced EGFR autophosphorylation in an HN-5 head and neck cancer mouse xenograft model.{69208} Formulations containing erlotinib have been used in the treatment of various cancers.

• Artikelnummer: CAY22101
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22101-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung