Product Description: Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C55H86O24
References: [1]Yang XW, et al. Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis. J Nat Prod. 1999 Nov;62(11):1510-3./[2]Wang Y, et al. Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression. Oncotarget. 2016 Apr 26;7(17):23684-99.
CAS Number: 123748-68-5
Molecular Weight: 1131.26
Compound Purity: 99.59
Research Area: Cancer; Infection
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: HIV Protease
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