Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (5aR)-9S-[[4,6-O-ethylidene-ß-D-glucopyranosyl]oxy]-5R,8,8aR,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1R,3-dioxol-6(5aH)-one
Purity: ≥98%
Formula Markup: C29H32O13
Formula Weight: 588.6
CAS Number: 33419-42-0
Notes: Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM).{21619,21623} It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM).{21620} It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A (Item No. 12088).{47188} Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM).{21622} Formulations containing etoposide have been used in combination therapy in the treatment of cancer.
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