Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-ethylidene-ß-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3-methoxy-5-(methoxy-d3)phenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C29H29D3O13
Formula Weight: 591.57476
Notes: Etoposide-d3 is intended for use as an internal standard for the quantification of etoposide (Item No. 12092) by GC- or LC-MS. Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM).{21619,21623} It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM).{21620} It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A (Item No. 12088).{47188} Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM).{21622} Formulations containing etoposide have been used in combination therapy in the treatment of cancer.
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