(±)-EX-527, CAS 49843-98-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Purity: ≥98%

Formula Markup: C13H13ClN2O

Formula Weight: 248.7

CAS Number: 49843-98-3

Notes: EX-527 is an inhibitor of sirtuin 1 (SIRT1; IC50 = 0.098 µM).{48663} It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7 cells.{48664}

• Artikelnummer: CAY10009798-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10009798-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK