EX229, CAS 1219739-36-2

Product Description: EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.

Applications: Metabolism-sugar/lipid metabolism

Formula: C24H18ClN3O3

References: [1]Xiao B, et al. Structural basis of AMPK regulation by small molecule activators. Nat Commun. 2013;4:3017./[2]Bultot L, et al. Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719.

CAS Number: 1219739-36-2

Molecular Weight: 431.87

Compound Purity: 98.92

Research Area: Metabolic Disease

Solubility: DMSO : 13 mg/mL (ultrasonic;warming)

Target: AMPK

• Artikelnummer: MEXHY-112769-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-112769-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK