Exisulind, CAS 59864-04-9

Product Description: Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac[1]. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications[2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C20H17FO4S

References: [1]Kitamura S, Tatsumi K. In vitro metabolism of sulindac and sulindac sulfide: enzymatic formation of sulfoxide and sulfone. Jpn J Pharmacol. 1982 Oct;32(5):833-8./[2]Zheng X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Lett. 2012 Jan 2;586(1):55-9.

CAS Number: 59864-04-9

Molecular Weight: 372.41

Compound Purity: 98.03

Research Area: Metabolic Disease; Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Aldose Reductase

• Artikelnummer: MEXHY-13633-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-13633-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK