Ezutromid, CAS 945531-77-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-(ethylsulfonyl)-2-(2-naphthalenyl)-benzoxazole

Purity: ≥98%

Formula Markup: C19H15NO3S

Formula Weight: 337.4

CAS Number: 945531-77-1

Notes: Ezutromid is a modulator of utrophin production.{32729} It upregulates utrophin production in mouse myoblasts (EC50 = 0.91 µM in a reporter assay).{68213} It inhibits the activity of the cytochrome P450 (CYP) isoform CYP1A2 in pooled human liver microsomes (IC50 = 5.4 µM).{68214} Chronic administration of ezutromid (50 mg/kg) increases utrophin protein levels in the heart, increases grip strength, and decreases fatigue, indicated by distance traveled during forced exercise, in the mdx mouse model of muscular dystrophy.{32729}

• Artikelnummer: CAY20309-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20309-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK