Target Synonym: PKC;PKCI;FKBP1A;FKBP-12;FKBP-1A;FKBP1;FKBP12;PKC12;PKCI2;PPIASE;12 kD;12 kDa FK506-binding protein;12 kDa FKBP;Calstabin 1;FK506 binding protein;FK506 binding protein 1;FK506 binding protein 12;FK506 binding protein 1A;FK506 binding protein 1A (12kD);FK506 binding protein 1A 12kDa;FK506 binding protein T cell 12 kD;FK506 binding protein12;FK506-binding protein 1A;FKB1A;FKBP 12;FKBP 1A;FKBP12 Exip3;FKBP12C;Immunophilin FKBP12;Peptidyl prolyl cis trans isomerase;Peptidyl-prolyl cis-trans isomerase FKBP1A;PPIase FKBP1A;Protein kinase C inhibitor 2;Rotamase;T cell
Background: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK503 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Immunogen: Recombinant Human FKBP1A protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;
Calculated MW: 12 kDa
Observed MW: 15 kDa
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