Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione
Purity: ≥98%
Formula Markup: C25H28O6
Formula Weight: 424.5
CAS Number: 52328-97-9
Notes: A synthetic curcuminoid; inhibits LPS-induced increases in nitrite, an indicator of NO production, TNF-α, IL-1β, and IL-6 levels in primary mouse macrophages at 1, 5, or 10 µM; reduces STAT3 DNA binding activity in MDA-MB-231 cell nuclear extracts at 10 µM; decreases viability in combination with doxorubicin in MDA-MB-231 cells at 5 µM; reduces tumor volume and vasculature in a PANC-1 pancreatic cancer mouse xenograft model at 50 mg/kg per day; decreases ear volume in a rat model of croton oil-induced ear edema at 15 or 45 mg/kg; reduces the number of infiltrating neutrophils, lymphocytes, and macrophages in BALF in a mouse model of dust mite- and ragweed-induced acute airway inflammation at 15 mg/kg
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