Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[2-amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-carbamic acid, ethyl ester, 2Z-butenedioate
Purity: ≥95%
Formula Markup: C15H17FN4O2 / C4H4O4
Formula Weight: 420.4
CAS Number: 75507-68-5
Notes: Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ).{45470,45471,45472} It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice.{45471} Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT+ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine.{45472} Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.{45470,45473}
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