Shelf life (days): 180.0
Assay Range: 7.8-1,000 pg/ml
Sensitivity: 80% B/B0: ~16 pg/ml
Cross Reactivity: Fluprostenol 100%; 2,3-dinor Fluprostenol 100%; Fluprostenol lactone diol 100%; 9-keto Fluprostenol 83%; 15(S)-Fluprostenol isopropyl ester 27%; 11-keto Fluprostenol 15.2%; Fluprostenol isopropyl ester 10%; 9-keto Fluprostenol isopropyl ester 8.5%; 15-keto Fluprostenol free acid 0.9%; 15-keto Fluprostenol isopropyl ester 0.02%; Latanoprost <0.01%; Latanoprost (free acid) <0.01%; 15-epi Latanoprost <0.01%; 5,6-trans Latanoprost <0.01%; tetranor-PGEM <0.01%; tetranor-PGFM <0.01%; Prostaglandin D2 <0.01%; Prostaglandin E2 <0.01%; Prostaglandin E2 Ethanolamide <0.01%; 6-keto Prostaglandin F1α <0.01%; Prostaglandin F2α <0.01%; Prostaglandin F2α Ethanolamide <0.01%; 5-trans Prostaglandin F2α <0.01%; 17-phenyl trinor Prostaglandin F2α <0.01%; 17-phenyl trinor Prostaglandin F2α ethyl amide <0.01%; Thromboxane B2 <0.01%; Unoprostone <0.01%; Unoprostone isopropyl ester <0.01%
Formula Weight: 0.0
Notes: Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity. The isopropyl ester of fluprostenol has been approved for use as an ocular hypotensive drug for the treatment of glaucoma and is sold under the Alcon trade name Travoprost. Acting as a prodrug, Fluprostenol isopropyl ester is converted by esterase activity in the cornea to yield the corresponding active free acid, (+)-fluprostenol. Cayman’s Fluprostenol ELISA is a sensitive detection method for measuring the free acid form of fluprostenol. The assay also detects the isopropyl ester form of fluprostenol, but with less sensitivity. The assay has been validated for use in aqueous humor samples.
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