Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (±)-2-fluoro-a-methyl-[1,1'-biphenyl]-4-acetic acid
Purity: ≥99%
Formula Markup: C15H13FO2
Formula Weight: 244.3
CAS Number: 5104-49-4
Notes: (±)-Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).{1286} In vivo, (±)-flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.{39761} (±)-Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.{39762} Formulations containing (±)-flurbiprofen have been used to manage pain and inflammation associated with arthritis.
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