Product Description: Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels[1][2].
Applications: Cancer-programmed cell death
Formula: C11H14N4O4
Citations: Cell Metab. 2024 Sep 28:S1550-4131(24)00366-8./Chem Sci. 2024 Mar 4./Int J Biol Sci. 2023; 19(3):772-788./J Med Chem. 2023 May 3./Nat Commun. 2017 Aug 14;8(1):241. /Plant J. 2023 Dec 4./SSRN. 2024 Mar 14./bioRxiv. 2019 Oct. /Biosens Bioelectron. 2020 Dec 1;169:112616./Cell Rep. 2020 May 12;31(6):107640./Cell. 2019 Oct 31;179(4):864-879.e19./J Biol Chem. 2022 May;298(5):101876./Nat Metab. 2020 Jul;2(7):635-647./Neurochem Res. 2024 Nov 16;50(1):13./Nucleic Acids Res. 2020 Sep 25;48(17):e101.
References: [1]Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895./[2]Bantia S, et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent. Int Immunopharmacol. 2001 Jun;1(6):1199-210.
CAS Number: 209799-67-7
Molecular Weight: 266.25
Compound Purity: 99.88
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Apoptosis;Nucleoside Antimetabolite/Analog
Deutsch
English
