Target Synonym: PRR;CDw;PPR;PVRL;Poliovirus receptor-like;Poliovirus receptor related;Poliovirus receptor related protein;PVRR;DKFZP566B;CD113;CDw113;DKFZP566B0846;FLJ90624;Nectin-3;Poliovirus receptor related 3;Poliovirus receptor related protein 3;Poliovirus receptor-like 3;Poliovirus Receptor-Related Protein 3;PPR3;PVRR3;PRR3;PVRL3;NECTIN3;Nectin-3;PRR3;CDw113
Background: Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation.
Immunogen: Recombinant Human CD113/Nectin-3 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:50-1:200
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