Target Synonym: NKSF;IL-12/IL-23 p;IL-12 subunit p;NK cell stimulatory factor chain;NK cell Stimulating Factor Chain;CLMF;CLMF p;IL12 p;CLMF2;Cytotoxic lymphocyte maturation factor 40 kDa subunit;Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40);IL12;IL-12 p40;IL12 p70;IL-12 p70;IL-12/IL-23 p40;NK cell Stimulating Factor Chain 2;p40;IL-12B;NKSF2;Interleukin-12 subunit beta;CLMF p40;IL-12 subunit p40;NK cell stimulatory factor chain 2;IL 12B;Il12b
Background: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.1 PublicationAssociates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Immunogen: Recombinant Mouse IL12B Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:100-1:500
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